The most important world in the Imperium is Arrakis, known also as Dune due to being a vast planet-size desert. Here is where one finds spice, a substance required for interplanetary travel. Whomever controls Arrakis controls the spice. And who controls the spice controls the universe.
Dune: War for Arrakis puts players in the role of the heads of Houses Harkonnen and Atreides during the events of the Desert War. They each have their own goals and resources to ensure that, in the end, control of the spice is theirs.